This issue seems to trouble many new starters in GMP. Should the water purification be deionization (DI), or via reverse osmosis (RO)?The answer actually lies on the final output desired. The output quality must be able to achieve the desired specification for a Purified Water, usually in compliance to BP or USP. So, you can use either DI, or RO, or combination of both, as long as the final output meet the pre-determined specification.
The difficult and expensive portion is to ensure that the water purification design is able to consistently produced water of the desired specification. There should be a pre-treatment water treatment system, before the actual purification stage. Contact materials used after the purification stage, should be inert and not promote microbial growith, and there should be no dead legs that allow 'obstructive' flow within the water system.
Put your trust in the expert to design the best water system, that falls within your budget. Do not take risk by designing your own system if you do not have the experience and knowledge in this subject.
Finally, always qualify your water system before using it.
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